Nowadays, colorectal cancer (CRC) is considered to be the third most deadly and the fourth most commonly detected cancer in the world ( 1). Here, we explore the possibility of the use of cannabinoids for modulation of immunotherapy of colon cancer and discuss possible advantages and limitations. By far less information exists on the potential of the use of cannabis in combination with immunotherapy. Because of that, they are proposed as adjunct therapy for many malignancies. Cannabinoids were shown to modulate the pathways involved in cell proliferation, angiogenesis, programmed cell death and metastasis. In the recent decade, several reports suggest the effectiveness of cannabinoids and Cannabis sativa extracts for inhibiting cancer proliferation in vitro and in vivo, including intestinal malignancies. Therefore, new treatment strategies are required. However, cancer cells may become resistant to immunotherapy and escape immune surveillance by obtaining genetic alterations. This type of therapy boosts the patient's immune system ability to fight the malignant tumor. The most promising cancer treatment nowadays is immunotherapy which is also called biological or targeted therapy. ![]() Unfortunately, currently, no effective curative option exists for this type of malignancy.
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